Table 3:

Systemic menopausal hormone therapy products available in Canada

Generic name	Dosage	Relative cost per year, before pharmacy dispensing fees^*^†
Conjugated estrogens	0.3–0.625 mg once daily	+
17-β-estradiol (micronized)	0.5–1 mg once daily	+
Transdermal patch
Twice weekly 17-β-estradiol patches	25–50 μg twice weekly	++
Transdermal gel
17-β-estradiol gel	For 0.06% gel, 0.75 mg estradiol per 1.25 g metered dose (1 actuation). 1–2 metered doses/actuation daily	++
Progestins
Oral
Medroxyprogesterone	2.5 mg daily for continuous regimen or 5 mg daily for 12–14 d/mo	+
Progesterone (micronized)	100 mg daily for continuous regimen or 200 mg daily for 12–14 d/mo for cyclic regimen	+
Intrauterine
Levonorgestrel intrauterine system^‡	52 mg per intrauterine system for 5 years	+
Combination hormone therapy preparations
Oral
17-β-estradiol and NETA	1 mg 17-β-estradiol and 0.5 mg NETA once daily	+++
17-β-estradiol and NETA	0.5 mg 17-β-estradiol and 0.1 mg NETA once daily	+++
17-β-estradiol and DRSP	1 mg 17-β-estradiol and 1 mg DRSP once daily	++
Transdermal patch
17-β-estradiol and NETA	50 μg 17-β-estradiol and 140 mg NETA patch twice weekly	++
17-β-estradiol and NETA	50 μg 17-β-estradiol and 250 mg NETA patch twice weekly	++
TSEC
Conjugated estrogen and bazedoxifene	0.45 mg conjugated estrogen and 20 mg bazedoxifene once daily	+++
Synthetic steroid
Tibolone	2.5 mg once daily	+++

Note: DRSP = drospirenone, NETA = norethindrone acetate, TSEC = tissue selective estrogen complex.
↵* Available from www.rxfiles.ca.
↵† Range of costs: + = < $300, ++ = $301–1000, +++ = > $1001.
↵‡ Not approved for menopausal hormone therapy by Health Canada.