Delivery of pharmacogenomic testing in the base-case analysis for patients with prevalent and newly diagnosed major depressive disorder (MDD), by MDD severity
| Type | Severity* | Receipt of pharmacogenomic testing |
|---|---|---|
| Prevalent MDD | Mild | If MDD recurs as a moderate or severe episode |
| Moderate-to-severe | Before any prescription | |
| Newly diagnosed MDD | Mild | If MDD recurs as a moderate or severe episode |
| Moderate-to-severe | After 1 unsuccessful medication trial (stopped because of adverse event, no remission or after recurrence) |
↵* The frequency distributions of MDD severity in patients with newly diagnosed and prevalent MDD were extracted from Ferrari and colleagues, (34) and Kessing and colleagues, (35) respectively. People with mild depression have constant sadness, have lost interest in usual activities, sleep badly, feel tired and have trouble concentrating, but can still function in daily life with extra effort. People with moderate depression have some difficulty functioning in daily life and sometimes think about harming themselves, in addition to the other features of mild depression. People with severe depression have overwhelming and constant sadness, cannot function in daily life and sometimes lose touch with reality and want to harm or kill themselves. (34)