Base-case analyses comparing screening with no screening for abdominal aortic aneurysms (AAAs) over a lifetime
| Variable* | Point estimate (95% CI) | Absolute difference or value | |
|---|---|---|---|
| Screening | No screening | ||
| Males aged 65 yr | |||
| Life-years | 18.96 (18.46–19.43) | 18.92 (18.41–19.42) | 0.04 |
| QALYs | 14.95 (14.55–15.31) | 14.91 (14.54–15.26) | 0.04 |
| Cost, $ | 332 (0–980) | 252 (0–798) | 80 |
| AAA-related deaths, % | 0.08 | 0.53 | −0.45 |
| No. needed to screen to prevent 1 AAA-related death | 222 | ||
| ICER, $ per QALY | 2418 | ||
| Females aged 65 yr | |||
| Life-years | 21.25 (20.75–21.72) | 21.23 (20.73–21.72) | 0.02 |
| QALYs | 16.20 (15.88–16.54) | 16.19 (15.84–16.53) | 0.01 |
| Cost, $ | 87 (0–534) | 76 (0–453) | 11 |
| AAA-related deaths, % | 0.04 | 0.21 | −0.17 |
| No. needed to screen to prevent 1 AAA-related death | 588 | ||
| ICER, $ per QALY | 740 | ||
| Males aged 75 yr | |||
| Life-years | 12.05 (11.65–12.52) | 12.04 (11.64–12.50) | 0.01 |
| QALYs | 8.75 (8.48–9.03) | 8.74 (8.46–9.03) | 0.01 |
| Cost, $ | 261 (0–883) | 154 (0–513) | 107 |
| AAA-related deaths, % | 0.07 | 0.34 | −0.27 |
| No. needed to screen to prevent 1 AAA-related death | 370 | ||
| ICER, $ per QALY | 9697 | ||
| Females aged 75 yr | |||
| Life-years | 13.97 (13.53–14.41) | 13.96 (13.52–14.40) | 0.01 |
| QALYs | 9.88 (9.61–10.15) | 9.88 (9.61–10.14) | 0 |
| Cost, $ | 87 (0–487) | 71 (0–407) | 16 |
| AAA-related deaths, % | 0.03 | 0.17 | −0.14 |
| No. needed to screen to prevent 1 AAA-related death | 714 | ||
| ICER, $ per QALY | 2349 | ||
Note: CI = credible interval, ICER = incremental cost-effectiveness ratio, QALY = quality-adjusted life year.
↵* All values represent average (per individual) findings. Costs were adjusted to 2022 Canadian dollars, and costs and outcomes were discounted at 1.5% per year.