Risk of fracture at 1- and 3-year landmark (propensity score–matched)
| Characteristic | 1-year landmark analysis | 3-year landmark analysis | ||||
|---|---|---|---|---|---|---|
| ULT not prescribed rate* (95% CI) | ULT prescribed rate (95% CI) | HR (95% CI) | ULT not prescribed rate (95% CI) | ULT prescribed rate (95% CI) | HR (95% CI) | |
| Overall | 62.0 (54.3–70.8) | 62.7 (55.0–71.6) | 1.01 (0.84–1.22) | 65.3 (58.5–72.8) | 65.2 (58.5–72.7) | 1.00 (0.85–1.16) |
| Vertebral | 8.3 (5.8–12.0) | 7.7 (3.7–8.8) | 0.68 (0.39–1.20) | 9.0 (6.7–12.1) | 6.5 (4.6–9.1) | 0.71 (0.45–1.12) |
| Nonvertebral fracture | 47.1 (40.4–54.9) | 51.9 (44.9–60.0) | 1.10 (0.89–1.36) | 50.6 (44.7–57.3) | 52.1 (46.1–58.9) | 1.03 (0.87–1.22) |
| Wrist | 19.2 (15.1–24.4) | 21.1 (16.8–26.5) | 1.10 (0.79–1.53) | 17.9 (14.6–22.1) | 18.0 (14.6–22.1) | 1.00 (0.74–1.34) |
| Hip | 18.4 (14.4–23.5) | 23.1 (18.6–28.7) | 1.25 (0.90–1.75) | 24.3 (20.3–29.0) | 25.2 (21.2–30.1) | 1.04 (0.81–1.34) |
| Humerus | 9.5 (6.5–13.3) | 7.7 (5.3–11.2) | 0.81 (0.49–1.35) | 8.4 (6.2–11.4) | 8.90 (6.6–11.4) | 1.06 (0.70–1.62) |
Note: CI = confidence interval, HR = hazard ratio, ULT = urate-lowering therapy.
↵* Per 10 000 person-years.