The objective of this review is to examine the effects of changes in the individual components of musculoskeletal fitness on indicators of health status. Available evidence regarding the impact of changes in musculoskeletal fitness on indicators of health status is summarized and evaluated. Intervention programs designed specifically to enhance musculoskeletal fitness have been effective in improving several indicators of health status including glucose metabolism, obesity, bone health, independent living, the incidence of falling and associated injuries, and/or psychological well-being. An enhanced musculoskeletal fitness is associated with an improvement in health status.