658 CMAJ, June 14, 2016, 188 (9) who received clopidogrel after myocardial in farction
showed that concurrent use of omepra zole was associated with an increased risk of re …

There have been recent concerns about the safety of proton pump inhibitors (PPIs). We
focus here on 3 specific concerns—the possible interaction between PPIs and clopidogrel …

The potential association between major adverse cardiovascular events (MACE) and
concomitant treatment with proton pump inhibitors (PPIs) and clopidogrel has been debated …

Background Recent studies have suggested an adverse interaction between proton pump
inhibitors (PPI) and clopidogrel. Aim To perform a meta‐analysis of cardiovascular outcomes …

Clopidogrel, an antiplatelet agent, is increasingly prescribed for patients with recent stroke,
myocardial infarction, acute coronary syndrome, and/or patients post-coronary stent …

Background Data from pharmacokinetic and pharmacodynamic studies indicate that the
adverse clopidogrel–proton pump inhibitor (PPI) interaction may vary between PPIs, with …

BACKGROUND AND AIMS: Conclusions from clinical studies and previous meta-analyses
were inconsistent regarding the cardiovascular effects of concomitant use of proton pump …

Gastroenterologists frequently prescribe proton pump inhibitors (PPIs) for the prevention of
nonsteroidal antiinflammatory drug-induced upper gastrointestinal (GI) bleeding. There is …

Aliment Pharmacol Ther 2011; 33: 77–88 Summary Background The association between
myocardial infarction (MI) and co‐administration of proton pump inhibitors (PPIs) and …

Introduction: Proton pump inhibitors (PPIs) are one of the most prescribed classes of drugs
worldwide as a first-line treatment of acid-related disorders. Although adverse effects are …