Purpose: To determine whether -interferon is effective in terminating viral replication and in
eradicating the carrier state in patients with chronic hepatitis B virus (HBV) infection. Data …

BACKGROUND & AIMS: The relative efficacies of licensed antiviral therapies for treatment-naive
chronic hepatitis B (CHB) infection in randomized controlled trials have not been …

Although hepatitis C virus (HCV) infection is very common, identification of patients during
acute infection is rare. Consequently, little is known about the immune response during this …

Because clearance of hepatitis B virus (HBV) infection is rarely, if ever, achievable, the
goals of therapy necessarily focus on prevention of bad clinical outcomes. Ideally, therapies …

In nonalcoholic fatty liver disease, hepatic gene expression and fatty acid (FA) composition
have been reported independently, but a comprehensive gene expression profiling in …

Hepatitis C virus (HCV) is a common infection worldwide, and in most persons, it leads to
persistent viremia and liver damage. Efforts to identify the correlates of protective immunity are …

Hepatitis C virus (HCV)-specific CTL have been found within the inflammatory infiltrate of the
liver of chronically infected individuals, but the breadth and specificity of the CTL response …

BACKGROUND: The effect of chronic hepatitis B (CHB) infection on health-related quality of
life (HRQoL) and health state utilities has not been well characterized.OBJECTIVE: To …

Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited
access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass …

Broadly directed hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTL) have been
identified from liver-infiltrating lymphocytes but have been more difficult to assess in …