Introduction The technological advances of sequencing methods during the past 20 years
have fuelled the generation of large amounts of sequencing data that comprise common …

In the area of drug development and clinical pharmacotherapy, a profound understanding of
the pharmacokinetics and potential adverse reactions associated with the drug under …

Pharmacokinetics plays a central role in understanding the significant interindividual
differences that exist in drug metabolism and response. Effectively addressing these …

Clinical implementation of pharmacogenetics (PGx) into routine care will elevate the current
paradigm of treatment decisions. However, while PGx tests are increasingly becoming …

(1) Background Pharmacological treatment for psychiatric disorders has shown to only be
effective in about one-third of patients, as it is associated with frequent treatment failure …

We present the case of Mr. B, who was part of a NIMH-funded, longitudinal, observational
study (2013 to 2016) that recruited unmedicated participants who were experiencing a …

Objective: This work was designed to describe the knowledge and perceptions of
pharmacogenomics (PGx) among pharmacists in the Canadian province of Manitoba …

Many patients with major depressive disorder (MDD) try multiple antidepressants before
finding one that works well and is tolerable. Pharmacogenomic (PGx) testing was developed …

Background Major depressive disorder (MDD) is a common, often recurrent condition and a
significant driver of healthcare costs. People with MDD often receive pharmacological …

• Access to, and public funding for, treatment options for MDD varies across Canada, and
evaluations of the cost-effectiveness of pharmacogenomic testing should take into account …