A major goal in human genetics is to use natural variation to understand the phenotypic
consequences of altering each protein-coding gene in the genome. Here we used exome …

The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing
the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a …

Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes 1 , 2 , 3 , 4 – 5 . Here we use exome …

The United Nations General Assembly calls for ecosystem restoration to be a primary
intervention strategy used to counter the continued loss of natural habitats worldwide, while …

Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression
and, in disease research, can be particularly illuminating when using the tissues directly …

The UK Biobank Pharma Proteomics Project (UKB-PPP) is a collaboration between the UK
Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …

Background The DiGeorge syndrome, the most common of the microdeletion syndromes,
affects multiple organs, including the heart, the nervous system, and the kidney. It is caused by …

APOL1 variants have been associated with renal phenotypes in blacks. To refine clinical
outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed clinical …

On 1 March 2019, the United Nations (UN) General Assembly (New York) declared 2021–2030
the “UN Decade on Ecosystem Restoration.” This call to action has the purpose of …

Background Acute respiratory distress syndrome (ARDS) is a common, but under-recognised,
critical illness syndrome associated with high mortality. An important factor in its under-…