Importance Head-to-head safety comparisons of the mRNA vaccines for SARS-CoV-2 are
needed for decision making; however, current evidence generalizes poorly to older adults, …

Purpose Consensus is needed on conceptual foundations, terminology and relationships
among the various self‐controlled “trigger” study designs that control for time‐invariant …

Background: In Canada, more than 2 million people live with osteoporosis, a disease that
increases the risk for fractures, which result in excess mortality and morbidity, decreased …

Antiresorptive medications have been explored for treating knee osteoarthritis (OA);
however, little data exist on the effects of today's more potent nitrogen‐containing oral …

Introduction COVID-19 booster vaccines are highly effective at reducing severe illness and
death from COVID-19. Research is needed to identify whether racial and ethnic disparities …

Bisphosphonates are first-line therapy for osteoporosis, with alendronate, risedronate, and
zoledronate as the main treatments used globally. After one year of therapy, bisphosphonates …

Glucocorticoid-induced osteoporosis (GIOP) leads to fractures in up to 40% of patients with
chronic glucocorticoid (GC) therapy when left untreated. GCs rapidly increase fracture risk, …

Background: An osteoporosis drug holiday is recommended for most patients after 3 to 5
years of therapy. Risedronate has a shorter half-life than alendronate, and thus the residual …

Background Dose reduction of direct oral anticoagulant (DOAC) medications is inconsistently
applied to older adults with multiple morbidities, potentially due to perceived harms and …

Background Sodium‐glucose cotransporter‐2 inhibitor (SGLT2I) use has increased among
community‐dwelling populations, but little is known about how clinicians have prescribed …