User profiles for Lehana Thabane
Lehana ThabaneProfessor and Associate Chair, Health Research Methods, Evidence, and Impact, McMaster … Verified email at mcmaster.ca Cited by 67402 |
[HTML][HTML] A tutorial on pilot studies: the what, why and how
Pilot studies for phase III trials - which are comparative randomized trials designed to
provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely …
provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely …
CONSORT 2010 statement: extension to randomised pilot and feasibility trials
The Consolidated Standards of Reporting Trials (CONSORT) statement is a guideline designed
to improve the transparency and quality of the reporting of randomised controlled trials (…
to improve the transparency and quality of the reporting of randomised controlled trials (…
Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress …
Context Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung
injury and acute respiratory distress syndrome. Instituting additional strategies to open …
injury and acute respiratory distress syndrome. Instituting additional strategies to open …
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial
Background Mobile (cell) phone communication has been suggested as a method to improve
delivery of health services. However, data on the effects of mobile health technology on …
delivery of health services. However, data on the effects of mobile health technology on …
[HTML][HTML] Defining feasibility and pilot studies in preparation for randomised controlled trials: development of a conceptual framework
We describe a framework for defining pilot and feasibility studies focusing on studies conducted
in preparation for a randomised controlled trial. To develop the framework, we undertook …
in preparation for a randomised controlled trial. To develop the framework, we undertook …
[HTML][HTML] Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform …
Background Recent evidence indicates a potential therapeutic role of fluvoxamine for
COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to …
COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to …
Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?
Background Results from apparently conclusive meta-analyses may be false. A limited
number of events from a few small trials and the associated random error may be under-…
number of events from a few small trials and the associated random error may be under-…
Drug treatments for covid-19: living systematic review and network meta-analysis
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …
Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: toward an empirical definition of hypotension
…, A Turan, RN Rodseth, J Cywinski, L Thabane… - …, 2013 - pubs.asahq.org
Background: Intraoperative hypotension may contribute to postoperative acute kidney injury
(AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors …
(AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors …
Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
ContextAdherence to antiretroviral therapy is a powerful predictor of survival for individuals
living with human immunodeficiency virus (HIV) and AIDS. Concerns about incomplete …
living with human immunodeficiency virus (HIV) and AIDS. Concerns about incomplete …