Background Vitamin K has been widely promoted as a supplement for decreasing bone loss
in postmenopausal women, but the long-term benefits and potential harms are unknown. …

Osteoporosis and resulting osteoporotic fractures are responsible for significant morbidity,
excess mortality, and health care costs in the developed world. Medical therapy for …

Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by heterotopic
ossification (HO) in connective tissues and painful flare-ups. In the phase 2 LUMINA-1 trial, …

Background Exemestane can prevent breast cancer in postmenopausal women. Because of
potential widespread use, we examined the safety of exemestane on bone health. Methods …

XLH is the most common heritable rickets. Affected children have high levels of circulating
FGF23 that cause hypophosphatemia with consequent rickets and lower limb deformity. …

Background Fibrodysplasia ossificans progressiva (FOP), an ultra-rare disorder caused by
mutations in the gene encoding activin A receptor type 1 (ACVR1), is characterized by painful …

Background: In Canada, more than 2 million people live with osteoporosis, a disease that
increases the risk for fractures, which result in excess mortality and morbidity, decreased …

Introduction: Osteoporosis and fragility fractures are important public health concerns.
Cathepsin K inhibitors, including odanacatib , are a novel class of medications for osteoporosis …

In this report, we describe 6 children with osteogenesis imperfecta with unusual stress
femoral fractures. All children were on long-term cyclic pamidronate treatment. All fractures …

Adequate calcium intake is important for optimal bone health. Assessing dietary calcium
intake, however, is neither widely done nor standardized in North American clinical practices. …